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KMID : 0984920170190020010
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Journal of Skin Barrier Research
2017 Volume.19 No. 2 p.10 ~ p.14
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Dermatologic Application of Autophagy Regulator
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Jeong Se-Kyoo
Park Kee-Don
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Abstract
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Autophagy can be defined as a self-digestive process, targeting internal or damaged organelles and misfolded proteins to lysosomal degradation. While its major role is a survival mechanism under stress conditions, such as nutrient restriction, it can also induce cell death under certain conditions. Changes in cellular energy status or inhibition of mTOR(mammalian target of rapamycin) are well-known activating signals of autophagy. In addition, sphingolipids metabolites, including sphingosine-1-phosphate and dihydroceramides, are also known to modulate the autophagy responses in various cells. Recently, increased attentions have been paid to the roles of autophagy process in skin(patho)physiology. Along with the potential involvement of autophagy in differentiation of epidermal keratinocytes, several studies also reported that autophagy activation alleviated local inflammation responses and skin aging. Previously, we have reported development of new autophagy activators in human epidermal keratinocytes. Significant anti-inflammatory activities and anti-aging effects were observed for those newly developed autophagy activators. In this talk, practical application of those developed compounds as cosmetic ingredients will be discussed.
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KEYWORD
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Autophagy, Anti-aging, Inflammation, Cosmetics, Pigmentation
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